Research

• Clinical trials: 7
• Editor – Retina: Clinical and Experimental Vision and Eye Research; peer-reviewed journal
• Invited Reviewer for Peer-Reviewed Journals: 3
• Publications (in-print and in-press): 41
• Lectures at International Meetings: 29
• Presentations at International Meetings: 46

Principal Investigator

1. EVER trial

With Dr Spaide I am the principal investigator of this trial, which evaluates aflibercept in patients with a pigment epithelial detachment despite ranibizumab. This is an investigator-sponsored trial (IST) with Regeneron.

I have been responsible for submitting the initial study proposal, drafting the study protocol and negotiating budgets for the trial. We have secured a budget of $400000.00 for this trial.

2. EYEBETES study

I am the principal investigator for this large cohort study which is supported by the Eyebetes Foundation.

Main Investigator

1. VIEW2 Study (Industry sponsored clinical trial – aflibercept for neovascular AMD; Liverpool)

2. IVAN trial (NHS sponsored clinical trial – ranibizumab compared to bevacizumab in neovascular AMD; Liverpool)

3. HOLD trial (Investigator Sponsored Trial (IST) – aflibercept for recalcitrant fluid despite treatment with ranibizumab; New York USA)
I helped design this trial with Dr Slakter (New York). I was instrumental in negotiating the budget of this trial with Regeneron. We secured a grant of $350000 for this trail.

4. LAST trial (Investigator Sponsored Trial (IST) – high dose ranibizumab 2mg in neovascular AMD; New York USA)

Sub-investigator

1. PDT Cohort Study (photodynamic with verteporfin for neovascular AMD study; Liverpool)

2. ISMO Study (Diabetic retinopathy imaging study; Liverpool)

Editor – Retina and Uveitis sections
Clinical and Experimental Vision and Eye Research

1. Eye
2. Canadian Journal of Ophthalmology
3. PLoS One

1. Kumar N. Unilateral endogenous endophthalmitis in an asymptomatic diabetic. Bombay Hospital Journal 2002 July; (44):483-485.

2. Evans S, Kumar N, Hughes D S. Kabuki syndrome: New ocular findings. Eye 2004 Mar; 18(3):322-4.

3. Kumar N, Jivan S, Topping N, Morrell AJ. Blindness and rectus muscle damage following spine surgery. Am J Ophthalmol. 2004 Nov; 138(5):889-91.

4. Kumar N, Khan M Y. Serratia endophthalmitis despite vancomycin and gentamicin in the irrigation fluid. Can J Ophthalmol. 2004 Dec; 39(7):778-9.

5. Kumar N, Mohamed M, Dabbs TR (published as Kumar A in error). Silicone oil pupil-block acute angle-closure glaucoma: optimal laser position. Retina 2004 Dec; 24(6):987.

6. Kumar N, Feyi-Waboso A. Intractable secondary glaucoma from hyphema following YAG Iridotomy. Can J Ophthalmol. 2005 Feb; 40(1):85-6.

7. Kumar N, McLure H. Patient comfort during phacoemulsification with sub-Tenons anaesthesia. J Cataract Refract Surg 2005 Feb; 31(2):261.

8. Kumar N, Jivan S. Serratia endoph letter reply. Can J Ophthalmol. 2005 Apr; 40 (2):133.

9. Kumar N, Goyder E, McKibbin M. The incidence of visual impairment due to diabetic
retinopathy in Leeds. Eye. 2006 Apr;20(4):455-9.

10. Kumar N, Jivan S, Thomas P, McLure H. Sub-Tenons anesthesia in patients on aspirin,
warfarin and clopidogrel. J Cataract Refract Surg. 2006 Jun;32(6):1022-5.

11. Kumar N, Pulpa V, Khan M Y. Intra-operative eye position following sub-Tenons anaesthesia for cataract surgery. Can J Ophthalmol. 2006 Aug;41(4):476-480.

12. Kumar N, Jivan S. The natural history of Vigabatrin-associated visual field defects in patients electing to continue their medication. Eye. 2006 Sep;20(9):1082-3.

13. Bansal S, Kumar N, Kyle G. Mechanism of bitemporal hemianopia. J Neuroophthalmol. 2006 Sep;26(3):233.

14. Kumar N, Hillier R, Marsh I. Diplopia after cataract surgery. Ophthalmology. 2006 Sep;113 (9):1685-6.

15. Kumar N, Jivan S. Intravenous cannulation skills of ophthalmology residents in the United Kingdom. J Cataract Refract Surg. 2006 Sep;32(9):1586-7.

16. Jivan S, Gamage L, Fourie L, Kumar N. Application of VAC dressing made easy. Ann Plast Surg. 2006 Sep;57(3):355-6.

17. Kumar N, Jivan S. Goldmann applanation tonometer calibration error checks: current practice in the UK. Eye 2007 Jun;21(6):733-4.

18. Hillier RJ, Kumar N. Tonometer disinfection practice in the United Kingdom: A national survey. Eye. 2008 Aug;22(8):1029-33.

19. Kumar N, Krishnan R, Wishart P. Deep sclerectomy for glaucoma secondary to intra-vitreal triamcinolone. Archives of Ophthalmology 2007 Sep;125(9):1284-6.

20. Kumar N, Jivan S. Ramadan and Eye Drops: The Muslim Perspective. Ophthalmology 2007 Dec;114(12):2356-60.

21. Kumar N, Dhir L, Jivan S, Prasad S. Pain during intra-vitreal injections: Topical anesthetic drops versus Subconjunctival anesthesia. Asian J Ophthalmol. 2008;10:185-187.

22. Kumar N, Theresa R, Harding SP, Pearce IA. Avastin: A cautionary note. Can J Ophthalmol. 2007 Oct;42(5):760-1.

23. Watts P, Kumar N, Ganesh A, Sastry P, Pilz D, Levin AV, Chitayat D. Chorioretinal dysplasia, hydranencephaly, and intracranial calcifications: pseudo-TORCH or a new syndrome? Eye. 2008 May;22(5):730-3.

24. Mahmood S, Kumar N, Lenfestey PM, Murjaneh S, Heimann H, Harding SP. Early response of retinal angiomatous proliferation treated with intravitreal pegaptanib: a retrospective review. Eye. 2009 Mar;23(3):530-5.

25. Kumar N, Jivan S. Ramadan and eye drops. Ophthalmology 2008 Aug;115(8): 1440-1.

26. Liazos S, Beare N, Broadbent B, Kumar N. Spontaneous resolution of Diabetic Macular Edema after discontinuation of Glitazones. Diabet Med. 2008 Jul;25(7):860-2.

27. Kumar N, Hillier RJ. Goldmann tonometer calibration: a national survey. Eye. 2009 Feb;23(2):413-5.

28. Kumar N, Jivan S, Buchan J. Compliance with prescribed treatment during Ramadan. Clin Experiment Ophthalmol. 2008 Oct;36(7):699.

29. Kumar N, Jivan S. Tonometer disinfection practice in the United Kingdom: A national survey. Eye. 2009 Aug;23(8):1748-9.

30. Kumar N, Dherani MK, Jivan S. Ramadan and Eye Drops: Perspective of Muslims in the United Kingdom. Br J Ophthalmol. 2009 Apr;93(4):551-2.

31. Kumar N, Prasad SD. Lens surgery in Marfans syndrome. Accepted in Techniques in Ophthalmology; January 2010.

32. Kumar N, Jivan S, Batterbury M. Tonometer calibration. Ophthalmology. 2009 Dec;116(12):2480-1.

33. Burgess P, O’Dowd J, Kumar N. Steroid treatment card’ compliance is suboptimal but can be improved. Eye, 2010 Aug;24(8):1409-10.

34. Reeves G, Kumar N, Beare N, Pearce I. Use of Staurenghi lens angiography in the management of posterior uveitis. Acta Ophthalmol. 2013 Feb;91(1):48-51.

35. Kumar N, Mrejen S, Fung AT, Marsiglia M, Loh BK, Spaide RF. Retinal pigment epithelial cell loss assessed by fundus autofluorescence imaging in neovascular age-related macular degeneration. Ophthalmology. 2013 Feb;120(2):334-41.

36. Fung AT, Kumar N, Vance SK, Slakter JS, Klancnik JM, Spaide RS, Freund KB. Pilot study to evaluate the role of high-dose ranibizumab 2.0 mg in the management of neovascular age-related macular degeneration in patients with persistent/recurrent macular fluid <30 days following treatment with intravitreal anti-VEGF therapy (the LAST Study). Eye (Lond). 2012 Sep;26(9):1181-7.

37. Kumar N, Marsiglia M, Mrejen S, Fung AT, Slakter J, Sorenson J, Freund KB. Visual and anatomical outcomes of intravitreal aflibercept in eyes with persistent subfoveal fluid despite previous treatments with ranibizumab in patients with neovascular age-related macular degeneration. Retina. 2013 Mar 30.

38. Arias J, Kumar N, Spaide R, Yannuzzi L, Shields J, Shields CL. The Seasick Choroid: A finding of enhanced depth imaging spectral-domain optical coherence tomography of choroidal lymphoma. Retinal Cases & Brief Reports. 7(1):19-22, Winter 2013.

39. Felcida V, Kumar N, Haynes R, Habal S, Tyagi AK. Retained silicone tip of diamond-dusted membrane scraper during vitrectomy in a valved cannula system. Eye. 2015, Apr;29(4):574-6.

40. Kumar N, Tsangaris P, Haynes RJ. Intra-orbital gas following sutureless small-gauge (23-gauge) vitrectomy masquerading as orbital cellulitis. Eye. 2014 Oct;28(10):1263-4.

41. Chandra A, Lai M, Mitry D, Banerjee PJ, Flayeh H, Negretti G, Kumar N, Wickham L. Ethnic variation in primary idiopathic macular hole surgery. Eye. 2017 Jan 13. [Epub ahead of print]

1. Optic disc assessment: Comparison of Heidelberg Retinal Topography and stereoscopic disc imaging
American Academy of Ophthalmology Annual Meeting, Los Angeles 2003

2. Locus heterogeneity in Leber’s congenital amaurosis genetic analysis in 11 consanguineous pedigrees
American Academy of Ophthalmology Annual Meeting, Los Angeles 2003

3. Serratia endophthalmitis after cataract surgery despite vancomycin and gentamicin in the irrigation fluid
European Society for Cataract and Refractive Surgery, Munich 2003

4. Does bleb-needling help! Our experience in Newport
14th Congress of the European Society of Ophthalmology, Madrid 2003

5. Screening of ocular side effects of Vigabatrin: The guidelines and current clinical practice
14th Congress of the European Society of Ophthalmology, Madrid 2003

6. Assess safety of single quadrant sub-Tenons anaesthesia for phacoemulsification
American Academy of Ophthalmology Annual Meeting, New Orleans 2004

7. Blindness following spine surgery
American Society of Cataract and Refractive Surgery, San Diego 2004

8. Incidence of blindness from diabetes in Leeds in 2002
Annual Congress of the Royal College of Ophthalmologists, Manchester 2004

9. Ramadan & Eye Drops: Perspective of the Indian Muslim
American Academy of Ophthalmology Annual Meeting, Chicago 2005

10. Patient comfort with Sub-Tenons anesthesia
American Society of Cataract and Refractive Surgery, Washington 2005

11. Compliance with eye drop use amongst Muslim patients during Ramadan: a prospective observational study
Annual Congress of the Royal College of Ophthalmologists, Birmingham 2005

12. Chorioretinal dysplasia, hydranencephaly and intracranial calcifications – A new syndrome?
15th Congress of the European Society of Ophthalmology, Berlin 2005

13. Fells Modification of Harada-Ito: Does One Surgery Fit All?
American Academy of Ophthalmology Annual Meeting, Las Vegas 2006

14. Patient comfort during intra-vitreal triamcinolone injections comparing topical and sub-conjunctival anaesthesia
American Academy of Ophthalmology Annual Meeting, Las Vegas 2006

15. Goldmann Tonometer calibration practice: A National Survey
Annual Congress of the Royal College of Ophthalmologists, Manchester 2006

16. Ocular treatment during Ramadan –Perspective of the British Muslim
Annual Congress of the Royal College of Ophthalmologists, Manchester 2006

17. Does intra-venous cannulation alter patient comfort during phacoemulsification under
sub-Tenons anesthesia and is it necessary?
Annual Congress of the Royal College of Ophthalmologists, Manchester 2006

18. Goldmann Tonometer disinfection practice: A National Survey
Annual Congress of the Royal College of Ophthalmologists, Manchester 2006

19. Radial optic neurotomy: Electrodiagnostic changes
Annual Congress of the Royal College of Ophthalmologists, Birmingham 2007

20. Intra-ocular pressure changes in the peri-operative period following intra-vitreal injections
Annual Congress of the Royal College of Ophthalmologists, Birmingham 2007

21. Compliance with glaucoma drops during Ramadan
Annual Congress of the Royal College of Ophthalmologists, Birmingham 2007

22. Viscocanalostomy for intractable glaucoma secondary to intra-vitreal triamcinolone
Congress of the European Society of Ophthalmology, Vienna 2007

23. Does the Fells Modification of the Harada-Ito Procedure Have a Vertical Effect?
American Academy of Ophthalmology Annual Meeting, New Orleans 2007

24. Early results of the treatment of Retinal Angiomatous Proliferations with Macugen
Annual Congress of the Royal College of Ophthalmologists, Liverpool 2008

25. To call or not to call………
Annual Congress of the Royal College of Ophthalmologists, Liverpool 2008

26. Which is better for intra-vitreal injections? Benoxinate or Proxymetacaine….
Annual Congress of the Royal College of Ophthalmologists, Liverpool 2008

27. Macugen: The Liverpool experience
Annual Congress of the Royal College of Ophthalmologists, Liverpool 2008

28. Did you feel that?? Intra-vitreal injections – The patients experience.
World Ophthalmology Congress, Hong Kong 2008

29. Tropicamide 1% – Its effect on intra-ocular pressure.
American Academy of Ophthalmology Annual Meeting, Atlanta 2008

30. Keratometric agreement between the Nidek ARK- 530, IOLMaster and Zeiss Ophthalmometer
American Academy of Ophthalmology Annual Meeting, Atlanta 2008

31. Could religious beliefs affect compliance with ocular treatment?
American Academy of Ophthalmology Annual Meeting, Atlanta 2008
* Selected as part of the official press release for the American Academy of Ophthalmologists. The paper has been quoted in numerous print media.

32. How often do we need a refracted visual acuity when treating patients with an anti-VEGF agent?
Annual Congress of the Royal College of Ophthalmologists, Birmingham 2009

33. Staurenghi lens angiography in the management of posterior uveitis
Annual Congress of the Royal College of Ophthalmologists, Birmingham 2009

34. Early visual and anatomical improvement in patients with neovascular age related macular degeneration resistant to pegaptanib switched to ranibizumab
Annual Congress of the Royal College of Ophthalmologists, Liverpool 2010

35. Compliance with steroid card use in a tertiary centre uveitis clinic
Annual Congress of the Royal College of Ophthalmologists, Liverpool 2010

36. New Trainees in Ophthalmology – Their experiences and perspectives
Annual Congress of the Royal College of Ophthalmologists, Liverpool 2010

37. Warfarin and intra-vitreal injections: Practice in the United Kingdom
Annual Congress of the Royal College of Ophthalmologists, Liverpool 2010

38. Measuring the service impact of Ranibizumab treatment for macular degeneration: Real life experience.
Annual Congress of the Royal College of Ophthalmologists, Liverpool 2010

39. Warfarin and intra-vitreal injections: Practice in the United Kingdom
World Ophthalmology Congress 2010, Berlin

40. Is the ‘0’ Test as Good as a Calibration Error Check for Goldmann Tonometers?
American Academy of Ophthalmology Annual Meeting, Chicago 2010

41. Retinal pigment epithelial cell loss assessed by fundus autofluorescence imaging in neovascular age-related macular degeneration
ARVO Annual Meeting, Fort Lauderdale 2012

42. Visual and anatomic outcomes of intravitreal Aflibercept in eyes with persistent fluid despite previous treatments with Ranibizumab and Bevacizumab
American Society of Retinal Specialists Annual Meeting, Las Vegas 2012

43. Visual Outcomes Following Early Anti-Tuberculous Treatment in Uveitis Patients with a Positive Interferon Gamma Release Assay Result
Annual Congress of the Royal College of Ophthalmologists, Birmingham 2012

44. The Role of Interferon Gamma Release Assays in the Diagnosis and Treatment of Chronic Refractory Uveitis
Annual Congress of the Royal College of Ophthalmologists, Birmingham 2012

45. Quantiferon Gold guided treatment of chronic refractory uveitis
Asia Pacific Association of Ophthalmology, Taipei 2016

46. Dengue related neuro-retinitis
Annual meeting of the Bombay Ophthalmology Association, Mumbai